Side effects of Sildenafil

Usually, side effects of Sildenafil-SZ are mild or moderate and transient. Fixed dose studies have shown that the frequency of some adverse events increases with increasing dose. General disorders: chest pain, general weakness. Allergic reactions: increased reactions sensitivity (including skin rash), Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome). From the central and peripheral nervous system: drowsiness, hypesthesia, ins lt, syncope, transient ischemic attack, seizures, including recurrent. On the part of the cardiovascular system: tachycardia, increased or decreased blood pressure, myocardial infarction, atrial fibrillation, unstable angina, sudden death. On the part of the respiratory system: nosebleeds. On the part of the digestive system: vomiting, nausea, dry mucous membrane membranes of the oral cavity. On the part of the organ of vision: eye pain, redness of the eyes / injection of the sclera, conjunctival damage, lacrimation, anterior ischemic optic neuropathy, retinal vascular occlusion , visual field defects. On the part of the organ of hearing: vertigo, tinnitus, deafness. On the part of the musculoskeletal system: myalgia. On the part of the reproductive system: prolonged erection and / or priapism, hematospermia and bleeding from the penis.
Symptoms: with a single dose of Sildenafil-SZ at a dose of up to 800 mg, adverse events were comparable to those with a lower dose, but were more common. Treatment: symptomatic treatment. Hemodialysis does not accelerate clearance of sildenafil, as the latter actively binds to plasma proteins and is not excreted by the kidneys.
Interaction with other drugs
When combined with ritonavir, the maximum single dose of buy Sildenafil over the counter should not exceed 25 mg, and the frequency of use should be 1 time per 48 hours. When used together with inhibitors of the cytochrome isoenzyme CYP3A4 (erythromycin, saquinavir, ketoconazole, itraconazole), the initial dose is Sililafil SZ should be 25 mg. To minimize the risk of developing postural hypotension in patients taking alpha-blockers, Sildenafil-SZ should only be started after hemodynamic stabilization is achieved in these patients. The feasibility of lowering the initial dose of sildenafil should also be considered.